Wesley Research Institute
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Led by Dr James Daveson, this program is a multidisciplinary collaboration involving patients, medical practitioners, hospitals and researchers. The research aims to deepen our understanding of autoimmune disease onset and progression, develop new diagnostic tools, create more effective interventions and ultimately find cures.

About this research theme

Coeliac disease is one of the most common autoimmune disorders, affecting 1 in 70 Australians. The disease is triggered by an intolerance to gluten found in wheat, rye and barley. Despite its prevalence, over 80% of sufferers remain undiagnosed, leading to increased risks of nutrient deficiencies, osteoporosis, malignancy and unnecessary healthcare costs.

The research program at WRI is focused on discovering new treatments and interventions to improve the lives of those with coeliac disease, including both investigator-led studies and sponsored clinical trials.

 

Coeliac Research Network

Wesley Research Institute is developing a new research network focusing on Coeliac Disease and immune health research.
Through this network, we expect to bring together coeliac disease experts, like gastroenterologists, paediatric gastroenterologists, surgeons, dieticians, nutritionists, nurses and mucosal immunologists, to work together to really progress the multi-disciplinary research program.
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A coeliac diet

Coeliac Disease Webinar Series

Are you or a loved one living with coeliac disease? Join us for an engaging and informative webinar series designed to explore the challenges, breakthroughs and future pathways in managing this complex disease.

“This series offers a unique opportunity to connect patients and clinicians with world-leading research and clinical insights,” says Dr James Daveson, Director of Coeliac Disease and Immune Health Research. “It’s an exciting step forward in delivering better care for coeliac patients across Australia.”
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Coeliac Disease and Immune Health Research Objectives

Improve understanding

The Gluten Threshold Study is investigating whether there is an amount of gluten that coeliac patients can tolerate. The results will also help to influence food safety standards.

Creating communities

Through the new Coeliac Research Network, we hope to bring patients, clinicians and scientists together to really progress the multi-disciplinary research program.

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to support research

Coeliac Disease and Immune Health Clinical Trials

Coeliac Disease Clinical Trials

Dr James Daveson and his team are developing a world leading multi-disciplinary research program for Coeliac Disease and Immune Health. However we can’t do this research without the coeliac community participating and volunteering to take part in clinical trials.

MOZART

The purpose of this study is to evaluate the safety of MTX-101 and better understand how this drug behaves in and affects the human body. 

Chugai

The research project is to evaluate the safety, effectiveness, immune response and blood levels of a single subcutaneous (SC) dose of DONQ52, an investigational product, versus a placebo for use in the treatment of Coeliac Disease.

FB102

The purpose of the study is to assess the safety of FB102 and better understand the positive and negative effects of the drug on participants with coeliac disease.  

Dr Falk

A phase IIb, double-blind, randomised, placebo-controlled trial to evaluate the efficacy and tolerability of ZED1227 in celiac disease subjects experiencing symptoms despite gluten-free diet

KAN101

This study will investigate the safety and tolerability of multiple intravenous (IV) doses of KAN-101 in patients with well-controlled Coeliac Disease. It is expected to act by reprogramming immune cells to become tolerant towards gluten.

Topas Therapeutics GmbH Study

A double-blind, randomized, placebo-controlled, phase 2a study  to evaluate the safety, tolerability, and pharmacodynamic (PD) effects of two infusions of escalating doses of TPM502 in adults diagnosed with Coeliac Disease (CeD).
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Dental Enamel Defects Study

Evaluating the prevalence of Coeliac Disease in children with Developmental Defects of Enamel.
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Gluten Threshold Study

This study will compare small doses of gluten; Each participant is allocated either a dose of gluten or a placebo (which contains no gluten at all) through a process known as randomisation. The dose of gluten/placebo will be administered in a “gluten challenge”, which means that participants will ingest the gluten/placebo and then be observed for side effects.

TEVA Study

A single-dose phase 1b, randomized, double-blind, placebo-controlled study to characterise the safety and tolerability of TEV-53408 administered subcutaneously in adults with Coeliac Disease 

Our Research Goals

Research into faster and more accurate diagnosis

Improve understanding around the causes of disease and better prediction of disease progression

Increase survival and quality of life for patients and families

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