Coeliac Disease and Immune Health - Wesley Research Institute
Wesley Research Institute

Wesley Research Institute is developing a world leading multi-disciplinary research program for Coeliac Disease and Immune Health.

About this research theme

An estimated 1 in 70 Australians have Coeliac Disease which is caused when an intolerance to gluten in wheat, rye and barley products triggers an autoimmune response that attacks the small intestine. However, it is estimated that more than 80 per cent of all Australian coeliac sufferers remain undiagnosed.

If left untreated, coeliac disease is associated with a three-fold increase in the risk of autoimmune diseases, osteoporosis, and malignancy, decreased quality of life, and a two to four-fold increase immortality.

The disease can also lead to juvenile tooth decay, malnutrition, depression, and infertility. Patients with coeliac disease can experience a wide range of symptoms such as abdominal pain, bloating, diarrhoea, constipation, fatigue and weight loss.

Coeliac Research Network

Wesley Research Institute is developing a new research network focusing on Coeliac Disease and immune health research.

Through this network, we expect to bring together coeliac disease experts, like gastroenterologists, paediatric gastroenterologists, surgeons, dieticians, nutritionists, nurses and mucosal immunologists, to work together to really progress the multi-disciplinary research program.

More info
A coeliac diet

Coeliac Disease and Immune Health Research Objectives

Improve understanding

The Gluten Threshold Study is investigating whether there is an amount of gluten that coeliac patients can tolerate. The results will also help to influence food safety standards.

Creating communities

Through the new Coeliac Research Network, we hope to bring patients, clinicians and scientists together to really progress the multi-disciplinary research program.

to support research

Coeliac Disease and Immune Health Clinical Trials

A person mixing baking ingredients in a bowl

Gluten Threshold Study

This study will compare small doses of gluten; Each participant is allocated either a dose of gluten or a placebo (which contains no gluten at all) through a process known as randomisation. The dose of gluten/placebo will be administered in a “gluten challenge”, which means that participants will ingest the gluten/placebo and then be observed for side effects.

Research Goals

Research into faster and more accurate diagnosis

Improve understanding around the causes of disease and better prediction of disease progression

Increase survival and quality of life for patients and families

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