Addressing a critical threat in respiratory medicine, this exploratory research project will investigate how inflammatory lung fluid sourced from Acute Respiratory Distress Syndrome (ARDS) patients may drive the spread of lung injury. The laboratory-based study will also aim to identify treatment approaches that may prevent the progression of such severe lung injury.

Research Objectives

Status

Current

Recruitment

Closed

Study location

The Wesley Hospital, Queensland Spatial Biology Centre (QSBC)

Study type

Investigator Initiated

    Lead investigator    
            Associate Professor Jeremy Cohen        

About this research project

Acute Respiratory Distress Syndrome (ARDS) is a serious lung condition that affects up to 20% of patients on breathing machines in Australian intensive care units. Despite years of research, doctors still do not fully understand how ARDS develops, and there is no specific treatment. The condition can be fatal in up to 50% of cases, and those who survive often face long-term health problems, impacting their quality of life and increasing healthcare costs. ARDS often begins with a localized lung injury.

This study aims to investigate whether inflammatory biofluid produced early by the injured lungs can spread inflammation and ultimately lead to ARDS. The project team will collect fluid from the lungs of ARDS patients and study how it affects inflammatory cells. This will help to understand if the fluid is harmful in humans and could lead to methods to prevent ARDS from developing.

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Cardiovascular & Critical Care

Laboratory investigation of the impact of inflammatory fluids on disseminating lung injury in ARDS