Wesley Research Institute
Donate
Now

This one year research project aims to compare two commonly used methods of draining the effusion to determine which one is best.

Research Objectives

Status

Current

Recruitment

Closed

Patient Group

Pleural Effusion

Study location

Wesley Research Institute

Study type

Investigator Initiated
find out if you’re eligible

Lead investigator

  • Dr Luke Garske

Clinical trial coordinators

  • Chris Henderson
  • Linda Pearce

Technical title

AMPLE-3: A Randomised Study Comparing Combined Indwelling Pleural Catheter (IPC) and Talc Pleurodesis with Video-Assisted Thoracoscopic Surgery (VATS) for the Management of Patients with Malignant Pleural Effusion

About this research project

The lung is covered by a thin lining which produces a very small amount of fluid to lubricate the lungs during breathing. Cancers can spread to this lining causing a build-up of fluid. This is called a malignant pleural effusion. The increased fluid can compress the lungs causing breathlessness. Draining the fluid can ease symptoms but it usually rapidly re-accumulates and needs further drainages.

This one year research project aims to compare two commonly used methods of draining the effusion to determine which one is best. One method involves a surgical procedure (VATS) and the other involves insertion of a long-term flexible chest tube (IPC). IPC and surgical pleurodesis are known to be safe procedures and are both commonly used; however, no one knows if one is better than the other at preventing the fluid from returning and further procedures being required.

 

Latest News

New Study Reveals Hidden Immune Activity in Cardiac Sarcoidosis Using Spatial Biology 

A new study led by researchers at Wesley Research Institute, published in the European Heart Journal—one of the world’s most widely read cardiology journals—marks a significant advance in cardiac sarcoidosis (CS) research.

New Research Program Transforming Cardiovascular Care

A new research program at Wesley Research Institute, led by Associate Professor Eliot Peyster, is bringing unique human tissue models, advanced spatial biology analyses, and implementation-focused computational and ‘AI’ tools into cardiovascular research.

Where Math Meets Medicine: Cooper’s Role in Transforming Cancer Care 

For Cooper, the future of cancer research lies at the intersection of numbers and biology. We caught up with Cooper, to learn how he’s diving into one of the most exciting and challenging areas of modern science: computational biology.
1 2 3 32
linkedin facebook pinterest youtube rss twitter instagram facebook-blank rss-blank linkedin-blank pinterest youtube twitter instagram