Dr Anuj Sehgal
About
Dr Sehgal completed his PhD at the Roslin Institute, University of Edinburgh (UK) (2013-2017), where he developed a long-term research passion for investigating gut homeostasis and what happens during dysfunction and disease. In 2018, Dr Sehgal joined the Mater Research Institute as a Research Officer to research the role of macrophages in growth and development. In October 2022, Dr Sehgal joined WRI as Senior Research Officer where he is leading several translational projects to understand the underlying biological mechanisms that regulate immune responses and whether this data can be quickly translated into clinical practice. Dr Sehgal’s research combines exploratory discovery-based research and translational research to understand triggers, disease progression, and both intestinal and extraintestinal manifestations of gastrointestinal disorders such as Coeliac Disease and Inflammatory Bowel Disease. Using this approach, he aims to understand the interlinked networks that regulate immune responses during disease.
Qualifications
PhD Immunology, University of Edinburgh, 2017
MRes Biomedical Science, Edinburgh Napier University, 2012
MSc Drug Design and Biomedical Science, Edinburgh Napier University. 2011
BSc HONS, Biochemistry, Heriot-Watt University, 2009
Featured Publications
Muir R, Sehgal A, Tye-Din JA, Daveson AJM. Undiagnosed coeliac disease identified by active case finding in first degree relatives of people with coeliac disease in Australia: a prospective observational study. Med J Aust. 2023 Oct 16;219(8):371-373. doi: 10.5694/mja2.52105. Epub 2023 Sep 16. PMID: 37716708.
Sehgal A, Carter-Cusack D, Keshvari S, Patkar O, Huang S, Summers KM, Hume DA, Irvine KM. Intraperitoneal transfer of wild-type bone marrow repopulates tissue macrophages in the Csf1r knockout rat without contributing to monocytopoiesis. Eur J Immunol. 2023 Aug;53(8):e2250312. doi: 10.1002/eji.202250312. Epub 2023 May 1. PMID: 37059596.
Sehgal A, Irvine KM, Hume DA. Functions of macrophage colony-stimulating factor (CSF1) in development, homeostasis, and tissue repair. Semin Immunol. 2021 Apr;54:101509. doi: 10.1016/j.smim.2021.101509. Epub 2021 Nov 4. PMID: 34742624.
Sehgal A, Donaldson DS, Pridans C, Sauter KA, Hume DA, Mabbott NA. The role of CSF1R-dependent macrophages in control of the intestinal stem-cell niche. Nat Commun. 2018 Mar 28;9(1):1272. doi: 10.1038/s41467-018-03638-6. PMID: 29593242; PMCID: PMC5871851.
Supervisions
Microbial Regulation of Host Inflammatory Pathways in Inflammatory Bowel Disease
Other supervisors – Associate Professor Jakob Begun (Mater Research Institute – UQ)
2020-2024 Doctor Philosophy — Associate Advisor (University of Queensland)
Professional Memberships
2018 – Current – Member of the Society of Leukocyte Biology
2019 – Current – Member of the Australasian Society of Immunology
2022 – Current – EMCR Researcher at Gastroenterological Society of Australia
2022 – Current – Gastroenterological Society of Queensland
2022 – Current – Member of the International Society for the Study of Celiac Disease
Affiliations
2023 – 2024 – Visiting Scientist QIMR Berghofer Medical Research Institute
2023 – 2027 – Adjunct Lecturer Charles Darwin University
2022 – 2025 – Honorary Research Fellow Mater Research Institute
2018 – 2025 – Honorary Fellow University of Queensland (FoM)
Links
