Neuroscience is the scientific study of the nervous system.
Neuroscience research at WMR explores a range of neurological diseases and disorders of the brain, spinal cord, and nerves in other parts of the body (peripheral nerves, which include motor and sensory nerves). Many of these diseases and disorders currently have no cure or effective treatment.
WMR aims to find better treatments, ways for earlier diagnosis and improve clinical outcomes and quality of life of patients with these devastating diseases through supporting and collaborating with clinicians at UnitingCare Health hospitals and academic researchers across several sub-specialties.
Research Manager: Dr Kelley Foster
A current focus in this research area is Neurodegenerative disease, which leads to debilitation and progressive degeneration of nerve cells in the brain and includes a number of conditions including Alzheimer’s disease, Parkinson’s Disease, Motor Neurone diseases, and Huntington’s Disease.
WMR Neuroscience researchers conduct investigations into:
- Peripheral Nervous System and Motor Unit Disorders (Motor Neurone Disease or Amyotrophic Lateral Sclerosis),
- Delirium and Dementia, including Alzheimer’s Disease and other forms of Dementia,
- Movement and cerebellar disorders (including Parkinson’s Disease, Huntington’s Disease, Friedreich’s Ataxia, Tourette’s Syndrome)
- Seizure Disorders
- Demyelinating Disorders (including Multiple Sclerosis)
- Stroke (Cerebrovascular Accident)
- Mental disorders (Schizophrenia, Bipolar Disorder, Obsessive-Compulsive Disorder, Posttraumatic Stress Disorder
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Current Research Projects
A physiotherapy exercise program with a self-management approach to improve physical activity in people with mild-moderate Parkinson’s disease: A RCT [Chief Investigator: Prof Sandra Brauer]
Defining inflammatory biomarkers in motor neuron disease patients to assist in clinical trial efficiency of the C5aR antagonist PMX205 [Chief Investigator: A/Prof Trent Woodruff]
Assessment of metabolic health in neurodegeneration: studies in motor neuron disease [Chief Investigator: Dr Shyuan Ngo]
Does genetic variation in genes controlling pro-inflammatory immune responses modulate outcomes of MIS416 treatment in patients with multiple sclerosis? [Chief Investigator A/Prof Judith Greer]
Using N-of-1 trials to identify responders to melatonin for sleep disturbance in Parkinson’s disease [Chief Investigator: A/Prof Jane Nikles]
Targeting peripheral inflammatory pathology in Parkinson’s disease using repurposed drugs [Chief Investigator: Dr Richard Gordon]
Use of mass spectrometry to identify circulating toxins in the people with ALS [Chief Investigator: Prof Pamela McCombe]
A Randomised, Double Blind, Placebo-controlled, Crossover Trial of Tetrahydrocannabinol and Cannabidiol for the treatment of Tourette’s syndrome [Chief Investigator: Dr Philip Mosley]
Endocrine and Appetite Targets and Therapies (EATT) for Motor Neuron Disease (MND): Investigating mechanisms of impaired appetite regulation and weight loss in MND [Chief Investigator: Dr Frederick Steyn]
A randomised, controlled phase 1 study to investigate the safety and efficacy of orally administered squalamine in subjects with Motor Neuron Disease [Chief Investigator: Prof Pamela McCombe]
Repurposing of clinically approved drugs for treatment of neurodegenerative diseases [Chief Investigator: Dr Richard Gordon]
Development and translation of a complement C5a receptor antagonist to clinical trials for Motor Neuron Disease and Huntington’s disease [Chief Investigator: A/Prof Trent Woodruff]
- Prof Sandra Brauer
- Dr Richard Gordon
- A/Prof Judith Greer
- Prof Pamela McCombe
- Dr Phil Mosley
- Dr Shyuan Ngo
- A/Prof Jane Nikles
- A/Prof John O’Sullivan
- Dr Frederick Steyn
- A/Prof Trent Woodruff
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