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MAGNIFI Trial: Lymph Node Imaging in Prostate Cancer


Project Background

Many prostate cancer patients currently undergo invasive and dangerous surgery to remove the surrounding lymph nodes which are at risk to become cancerous. This major surgery can lead to serious complications. The lack of a proper imaging technique to visualise the cancerous lymph nodes also results in inadequate treatment, unnecessary node dissections and a high percentage of recurrence with small nodes sometimes overlooked and inaccessible at surgery.

About the Project

Wesley Hospital urologists and WMR researchers Drs Les Thompson and Morgan Pokorny in collaboration with Prof Jelle Barentsz and Dr Thomas Hambrock from Radboud University Hospital in the Netherlands are investigating whether the combination of promising and emerging imaging technologies, could help avoid unnecessary lymph node dissection and improve the detection of lymph node metastases and their treatment.

This study is the forerunner in validating the combination of two imaging modalities in both intermediate to high risk prostate cancer patients and patients who have experienced treatment failure. The multi-modal approach can provide a better understanding of lymph node location and cancer status, decreasing the failure rate of current treatment protocols.

Expected Benefits

It is anticipated that the results of this study will improve treatment options and outcome prediction for prostate cancer patients and those at risk, providing a better solution for detecting the spread of cancerous cells into lymph nodes. The success of this study will also potentially enable the use of these imaging technologies for improving the diagnosis and management of other forms of cancer in the human body, notably breast cancer.