Predicting Responses to Treatment for Cardiac Amyloidosis

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Amyloidosis is a disease caused by deposits of an abnormal protein (amyloid) in tissue and organs. 

The most serious spread of amyloidosis is to the heart and if left untreated, average survival is five months.

High dose chemotherapy and bone marrow transplant can dramatically improve survival in certain cases of cardiac amyloidosis, with some patients showing a return of normal heart structure and function.

At present doctors do not know which patients will respond to treatment and which patients will not. 

As such, cardiologist Dr Ben Fitzgerald is seeking to identify differences in cardiac characteristics between patients who respond to treatment and those who do not in the hope of determining which patients will be more likely to respond to therapy.

This study, therefore, aims to identify key characteristics of the heart using MRI or echocardiography, to predict the response of patients to high doses of chemotherapy and bone marrow transplant in the treatment of cardiac amyloidosis.

It is hoped that the results of this study will help cardiologists make the best possible treatment recommendations for patients diagnosed with this disease.

This research was made possible thanks to the generosity of our donors and The Katharina Elizabeth Foundation.

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