Pilot Trial: Imaging Lymph Node Metastases In Prostate Cancer Patients
Pilot Trial: Imaging Lymph Node Metastases In Prostate Cancer Patients
Home » Pilot Trial: Imaging Lymph Node Metastases In Prostate Cancer Patients
Project Overview
Following prostate cancer treatment, a high proportion of patients (approx. 25%) relapse with local and/or distant recurrence. Metastasis of prostate cancer to a lymph node means that the disease has become systemic, with an increased risk of further disease progression. Therefore, the ability to detect the presence of lymph node metastases is an important prognostic factor that will influence future treatment options.
A more accurate non-invasive imaging technique, combined with existing treatment options, may lead to a therapeutic shift for patients who have in the past been restricted to palliative treatment.

Patients Required
Estimated completion
June 2021
Total Patients Required
60
Study Location
Wesley Medical Imaging
Project Aim
The aim of this trial is to assess two novel and recently developed imaging modalities against the current standard of pelvic lymph node dissection (PLND), which is a surgical procedure in the setting of suspected metastatic disease.
In addition, in the vast majority of men, we expect these imaging tests to return true negatives, allowing surgeons to confidently avoid performing what could be an unnecessary PLND.
Project Impact
If successful, this research will allow more accurate staging of disease by allowing detection of very small cancer deposits in lymph nodes that might have been missed by conventional imaging, or with a single modality alone (false negatives), and allow us to identify the location of these nodes.
The impact is that this imaging method could be applicable to any disease in which cancer spreads to lymph nodes, therefore the benefits are applicable to patients with colon cancer, bowel cancer, cervical cancer, melanoma, penile cancer, head and neck cancers.
Read more about prostate cancer staging and the trial here >>
Researchers
This research will facilitate more accurate staging of disease by allowing detection of very small cancer deposits in lymph nodes that may have been missed by conventional imaging.
Co-Investigators
Collaborating Institute
Presentations & Events
Prostate Cancer Research: Targeting Improvements in Men’s Health
Dr Nick Brown specialises in Interventional Radiology and is actively involved in research looking at innovative imaging techniques that could provide more accurate detection of cancer in lymph nodes.
In August 2019, he presented at Wesley Medical Research on his research project and what it will mean for people undergoing prostate cancer treatment.
Related Projects...
Reducing Risk of Catheter-Acquired UTI Post-Prostatectomy
Project Overview Catheter acquired urinary tract infections are one of the most common health care acquired infections. The daily acquisition...
Read MorePilot Trial: Imaging Lymph Node Metastases In Prostate Cancer Patients
Project Overview Following prostate cancer treatment, a high proportion of patients (approx. 25%) relapse with local and/or distant recurrence. Metastasis...
Read MorePilot Study: Repurposing Drugs in Malignant Glioma
Project Overview Malignant glioma is the most common primary tumour of the brain in adults and despite advances in surgical,...
Read MoreProfiling bacterial populations in breast cancer tissue
Project Overview Breast cancer is the most common female cancer with an incidence of 13,000 Australian women diagnosed each year...
Read MoreRelated News...
A Novel Prostate Cancer Trial is Delivering More Options for Patients
Prostate cancer is the third most common cause of death in Australia, with 20,000 diagnoses and close to 3,300 deaths...
Read MoreProstate Cancer Research: Targeting Improvements in Men’s Health
Prostate cancer is the third most common cancer death in Australia, with 20,000 diagnoses and close to 3,300 deaths each...
Read More