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Pilot Trial: Imaging Lymph Node Metastases In Prostate Cancer Patients

Pilot Trial: Imaging Lymph Node Metastases In Prostate Cancer Patients

Project Overview

Following prostate cancer treatment, a high proportion of patients (approx. 25%) relapse with local and/or distant recurrence. Metastasis of prostate cancer to a lymph node means that the disease has become systemic, with an increased risk of further disease progression. Therefore, the ability to detect the presence of lymph node metastases is an important prognostic factor that will influence future treatment options. 

A more accurate non-invasive imaging technique, combined with existing treatment options, may lead to a therapeutic shift for patients who have in the past been restricted to palliative treatment.

 

Seeking to improve accuracy in non-invasive imaging techniques

Patients Required

Estimated completion

June 2021

Total Patients Required

60

Study Location

Wesley Medical Imaging

Project Aim

The aim of this trial is to assess two novel and recently developed imaging modalities against the current standard of pelvic lymph node dissection (PLND), which is a surgical procedure in the setting of suspected metastatic disease.

 In addition, in the vast majority of men, we expect these imaging tests to return true negatives, allowing surgeons to confidently avoid performing what could be an unnecessary PLND.

Project Impact

If successful, this research will allow more accurate staging of disease by allowing detection of very small cancer deposits in lymph nodes that might have been missed by conventional imaging, or with a single modality alone (false negatives), and allow us to identify the location of these nodes.

The impact is that this imaging method could be applicable to any disease in which cancer spreads to lymph nodes, therefore the benefits are applicable to patients with colon cancer, bowel cancer, cervical cancer, melanoma, penile cancer, head and neck cancers.

Researchers

Dr Nick Brown
Interventional Radiologist & Lead Researcher

This research will allow more accurate staging of disease by allowing detection of very small cancer deposits in lymph nodes that might have been missed by conventional imaging.

Dr Nick Brown, Lead Researcher

Collaborating Institute

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