Pilot Trial: Imaging Lymph Node Metastases In Prostate Cancer Patients
Pilot Trial: Imaging Lymph Node Metastases In Prostate Cancer Patients
Project Overview
Following prostate cancer treatment, a high proportion of patients (approx. 25%) relapse with local and/or distant recurrence. Metastasis of prostate cancer to a lymph node means that the disease has become systemic, with an increased risk of further disease progression. Therefore, the ability to detect the presence of lymph node metastases is an important prognostic factor that will influence future treatment options.
A more accurate non-invasive imaging technique, combined with existing treatment options, may lead to a therapeutic shift for patients who have in the past been restricted to palliative treatment.
Patients Required
Estimated completion
June 2021
Total Patients Required
60
Study Location
Wesley Medical Imaging
Project Aim
The aim of this trial is to assess two novel and recently developed imaging modalities against the current standard of pelvic lymph node dissection (PLND), which is a surgical procedure in the setting of suspected metastatic disease.
In addition, in the vast majority of men, we expect these imaging tests to return true negatives, allowing surgeons to confidently avoid performing what could be an unnecessary PLND.
Project Impact
If successful, this research will allow more accurate staging of disease by allowing detection of very small cancer deposits in lymph nodes that might have been missed by conventional imaging, or with a single modality alone (false negatives), and allow us to identify the location of these nodes.
The impact is that this imaging method could be applicable to any disease in which cancer spreads to lymph nodes, therefore the benefits are applicable to patients with colon cancer, bowel cancer, cervical cancer, melanoma, penile cancer, head and neck cancers.
Read more about prostate cancer staging and the trial here >>
Researchers
Interventional Radiologist & Lead Researcher
This research will facilitate more accurate staging of disease by allowing detection of very small cancer deposits in lymph nodes that may have been missed by conventional imaging.
Co-Investigators
Collaborating Institute
Presentations & Events
Prostate Cancer Research: Targeting Improvements in Men’s Health
Dr Nick Brown specialises in Interventional Radiology and is actively involved in research looking at innovative imaging techniques that could provide more accurate detection of cancer in lymph nodes.
In August 2019, he presented at Wesley Medical Research on his research project and what it will mean for people undergoing prostate cancer treatment.
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