The following is an outline of all investigative research projects which were conducted during the year.
| Project title | Lay description | Research category |
|---|---|---|
| Modelling and characterisation of beams used in radiotherapy. | Investigating the accuracy and precision of radiation beams used in some radiotherapy treatments. | Cancer |
| The nature, prevalence and impact of sleep disturbance in caregivers of people with dementia. | The nature, prevalence and impact of sleep disturbance in caregivers of people with dementia. | Seniors Health |
| Endometriosis risk: defining risk mechanisms for two novel loci. | Understanding the genetic events that cause endometrial cancer. | Womens Health |
| Evaluation of a telehealth support system to improve self-management of physical activity and nutrition in people with Type 2 diabetes. | Lifestyle self management for diabetes sufferers. | Diabetes, Mens Health, Womens Health |
| Development of a new inhibitor compound to prevent Chlamydia trachomatis related infertility. | Preventing infertility due to prolonged infection by Chlamydia. | Womens Health |
| Genetic analysis of colorectal cancer tumour initiating cells. | Use a combination of state of the art cell isolation and RNA sequencing and analysis approaches with the aim of gaining new insights into the cells that initiate the spread of CRC. | Cancer |
| Kallikrein enzymes in ovarian cancer chemo-treatment. | Blocking the spread of ovarian cancer. | Cancer, Womens Health |
| Improved treatment outcomes for breast cancer patients through protein-based diagnosis with IGF family biomarkers. | Predicting breast cancer progression. | Cancer, Womens Health |
| Predicting recovery of language and communication after stroke using neuroimaging. | Recovery of speech after stroke or other brain injuries. | Neurology |
| A Phase II randomised controlled trial of Plasmalyte 148 vs bicarbonate as pump prime during cardiopulmonary bypass. | Preventing perfusion-induced inflammation during heart operations. | Cardiovascular, Mens Health, Womens Health |
| Hyperbaric Oxygen Radiation Tissue Injury Study “HORTIS” – Phase II. | Cancer, Mens Health, Womens Health, Wound and Bone Healing | |
| Executive dysfunction, perceived quality of life and CPAP treatment effects in obstructive sleep apnoea patients. | Helping patients with sleep apnoea function better. | Mens Health, Respiratory, Womens Health |
| Prevalent microorganisms detected in the female upper genital tract: The effect of these microorganisms on oocytes in vivo and in vitro and on outcomes. | Helping infertile women achieve successful assisted reproduction treatment. | Womens Health |
| Identification of Chlamydia trachomatis proteases which have a role during the immunopathological disease which results in infertility in women. | Is an immune response associated with infertility in women? | Womens Health |
| Maintaining lean body mass in women with breast cancer without gain – a pilot study. | Preventing fat gain after breast cancer treatment. | Cancer, Nutrition, Womens Health |
| Can we alter risk factors for oesophageal cancer with exercise? | Can we alter risk factors for oesophageal cancer with exercise? | Cancer |
| Cognitive functioning after adjuvant chemotherapy for early breast cancer – follow-up evaluation 5 years after treatment. | Long term changes in cognition in women treated for breast cancer. | Cancer, Womens Health |
| Cellular mechanisms of peritoneal sclerosis. | Understanding why long term dialysis in renal failure patients commonly fails. | Renal |
| Reducing adverse side effects in stereotactic radiosurgery. | More accurate targeting of radiotherapy beams for brain cancers. | Cancer, Neurology, Rehabilitation |
| Prospective evaluation of lymphoedema among patients with gynaecological cancer. | The onset and incidence of lymphoedema in women with gynaecological cancer. | Cancer, Womens Health |
| Postoperative enteral nutrition in patients with advanced epithelial ovarian cancer. | Improving nutrition of patients with advanced ovarian cancer. | Cancer, Nutrition, Rehabilitation, Womens Health |
| Tissue engineering bone – reconstruction of critical sized segmental bone defects in a large animal model. | Developing an animal model for repair of large bone damage. | Wound and Bone Healing |
| A potential marker and drug target for colorectal cancer. | Preventing spread of cancer cells. | Cancer |
| Randomised placebo controlled trial of Oralpremarin Vs Doxycycline for the treatment of mirena related vaginal bleeding. | Preventing bleeding with inter-uterine devices. | Womens Health |
| Microorganisms in the female upper genial tract and the host immune response: Effect on ART outcomes. | Bacteria in upper urogenital trace of women decrease success of assisted reproduction. | Womens Health |
| Chlamydia Trachomatis stress response proteins play a role during the immunopathological disease which results in tubal factor infertility in women. | Is an immune response to Chlamydia proteins associated with infertility in women? | Womens Health |
| Immune responses in stroke. | Immune response in stroke | Neurology |
| High throughput tissue analysis of novel candidate biomarkers of breast cancer progression. | Predictors of clinical outcome for breast cancer patients. | Cancer, Womens Health |
| Systemic versus local Gentamicin application for prophylaxis of implant-related Osteomyelitis, demonstrated by in vivo biophotonic imaging. | Prevention of bacterial bone infections. | Wound and Bone Healing |
| Asymptomatic upper genital tract infections in infertile couples and Assisted Reproductive Techology (ART) outcomes. | Infectious causes of infertility. | Womens Health |
| Understanding the heterogeneity of invasive lobular carcinomas of the breast: A combined approach using radiological, morphological and molecular analyses. | More accurate diagnosis of a common type of breast cancer. | Cancer, Womens Health |
| The site and nature of the visual defect underlying Amblyopia in humans. | Undertanding the pathology of a common eye disorder of children. | Neurology |
| PSA and related Kallikrein Serine Proteases are primary regulators of a more aggressive phenotype in prostate cancer. | Preventing aggressive forms of prostate cancer. | Cancer, Mens Health |
| Development and in vitro testing of slow release surface coatings for long-term infection prevention of orthopaedic implants. | Prevention of bacterial infections after orthopaedic (bone) implants. | Wound and Bone Healing |
| Efficacy of a gym-based exercise program in colorectal cancer survivors in the rehabilitation phase of cancer recovery. | Does a supervised exercise program assist in the recovery of colorectal cancer patients? | Cancer, Rehabilitation |
| Identifying the molecular basis for osteosarcoma metastasis. | Preventing the spread of bone cancer. | Cancer |
| That functional renal progenitor cells and renal stem cells can be generated from embryonic stem cells under appropriate conditions. | Deriving kidney cells from embryonic stem cells. | Renal |
| The effect of adjuvant chemotherapy on cognitive functioning in early breast cancer: Development of novel statistical approaches to evaluate the relationship between cognitive functioning and self report measures of quality of life.. | Changes in cognition of women treated by chemotherapy for breast cancer. | Cancer, Womens Health |
| Development of novel MRI biomarkers for the early detection of tumour recurrence from radiation induced brain injury. | Distinguishing new tumour growth from brain swelling/damage following chemotherapy or radiation treatment. | Cancer |
| Phase I trial of Dendritic Cell Vaccine treatment with oral Temozolamide for treatment of malignant glioma. | Dendritic Cell Vaccine for brain tumours. | Cancer, Neurology |
| Hyperbaric Oxygen Radiation Tissue Injury Study “HORTIS”. | To precisely determine the degree of benefit that hyperbaric oxygen therapy assists in the treatment of late radiation tissue injury. | Wound and Bone Healing |